Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions
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چکیده
منابع مشابه
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions
Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low-affinity tense (T) and multiple high-affinity relaxed (R) conformations. Positively selected residues allosterically modulate the equilibrium b...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2017
ISSN: 2375-2548
DOI: 10.1126/sciadv.1601944